curiosityseekerscience

 Structure and mechanism of attack of corona virus Let’s talk about the structure of COVID-19 Virus SARS COV 2 and also the mechanism of its entry. There are four families of corona Virus: - 1.        Alpha Corona virus 2.        Beta Corona Virus 3.        Gamma Corona Virus 4.        Delta corona Virus Out of which Alpha and Beta corona virus has shown transmission in Human being till now. Many outbreaks like the SARS (Severe Acute Respiratory Syndrome) outbreak in the 2002 and the MERS (Middle East Respiratory Syndrome) had been there in the past and both are related to the Beta Corona Virus family. Now let’s talk about the COVID-19 Virus (SARS COV 2) Structure of the COVID-19 virus SARS COV 2 is a virus of the family of Beta Corona Virus. It has a lipid bilayer which has 5 main structural proteins on the outer membrane of it and many...

Vaccine development for SARS COV2: - (reverse vaccinology approach.) The approach that we can take to develop vaccine is that we can identify the structure of the surface proteins present on virus and find the genome sequence responsible for the production of these proteins and can engineer the DNA sequence of it by using the recombinant DNA technology. We can copy the DNA sequence to make a huge number of it by the PCR method which will then be utilized to make proteins in another organism from where we would extract the proteins. These proteins will be given along with the adjuvants (i.e. substances that increases the efficacy of vaccine).to the patient so that the patient’s immune system can develop an immune memory which will be utilized whenever a virus attack. Two companies the Sanofi and the GSK have collaborated to develop vaccine against the SARs COV2. 1)       In this collaboration the Sanofi will be contributing the S-protein COVID-19 antig...

Treatment of Corona Virus(till date)                                                           Photo by  CDC  on  Unsplash There are 3 approaches that can be taken to treat the COVID-19. 1. To test the efficiency of drugs that are already available. 2. To bring out a new drug which are in their experimental phase. 3. To develop a new vaccine. One by one we will discuss all the three approaches 1)Drugs available already – A) Remdesivir (Drug Bank id- DB14761 ) This is the drug which was used during EBOLA outbreak during 2016. Remdesivir, or GS-5734, is an adenosine triphosphate analog. In 2017, its activity against the coronavirus family of viruses was also demonstrated. Remdesivir is also being researched as a potential treatment to SARS-CoV2, the coronavirus responsible for COVID-19. It is assumed to act...